Overview

Study of Pamidronate for the Prevention of Heterotopic Ossification

Status:
Withdrawn
Trial end date:
2010-06-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine whether Bisphosphonates in comparison to radiation therapy are effective in the prophylaxis and treatment of heterotopic ossification in high risk patients.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborator:
FAG (Freie Medizinische Gesellschaft)
Treatments:
Pamidronate
Criteria
Inclusion Criteria:

- Consecutive patients with established HO (Brooker grade III-IV), hospitalized for
resection of HO lesions

Exclusion criteria:

- Age <20 years

- Vitamin D deficiency (25OH-Vitamin D <30 ng/ml)

- Renal insufficiency (Clearance <50 ml/min)

- Intolerance of bisphosphonates

- Unable to provide informed consent