Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants
Status:
Completed
Trial end date:
2019-03-12
Target enrollment:
Participant gender:
Summary
This is a Phase 1, randomized, 2 way crossover, open label study of the effect of PF-04965842
on metformin (a probe for MATE1/2K activity) PK in healthy adult participants. The effect of
PF-04965842 on N1-methylnicotinamide (NMN; an endogenous biomarker for MATE1/2K) PK and its
correlation to the effect on metformin PK will also be assessed. Participants will be
randomized to 1 of 2 treatment sequences as described below. A total of 12 healthy male
and/or female participants will be enrolled in the study so that 6 participants will be
enrolled in each treatment sequence. Each treatment sequence will consist of 2 periods.