Overview

Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast

Status:
Recruiting
Trial end date:
2032-06-20
Target enrollment:
0
Participant gender:
All
Summary
A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery)chemotherapy and adjuvant (post-surgery) endocrine therapy in participants with high-risk, estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) early stage breast cancer.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Bristol-Myers Squibb
Treatments:
Albumin-Bound Paclitaxel
Cyclophosphamide
Estrogens
Nivolumab
Paclitaxel
Criteria
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Localized invasive breast ductal carcinoma, confirmed by the local pathologist, that
includes the following combined primary tumor and clinical node (cN) categories: T1c
(tumor size = 2 cm)-T2 (tumor size > 2 cm), cN1-N2 OR T3-T4, cN0-cN2. Note: Axillary
lymph node status must be assessed by fine needle biopsy or core biopsy.

- Estrogen receptor-positive (ER+) breast cancer (BC) and with or without progesterone
receptor (PgR) expression (determined on the most recently analyzed tissue sample
tested locally and confirmed by the central laboratory, as defined in the relevant
American Society of Clinical Oncology (ASCO)- College of American Pathologists (CAP)
Guidelines. Human epidermal growth factor receptor 2 (HER2-) BC tested in the local
laboratory, defined as a negative in situ hybridization test or an
immunohistochemistry (IHC) status of 0, 1+, or 2+.

- Tumor Grade 3 of ductal histology, Or Tumor Grade 2 of ductal histology having an ER
expression level percentage between 1-10%

- Must agree to provide primary breast tumor tissue at baseline and at surgery

- Must be deemed eligible for surgery

- Males and females must agree to follow specific methods of contraception, if
applicable, while participating in the trial

- Must have an Eastern Cooperative Oncology Group (ECOG) scale performance status of 0
or 1

Exclusion Criteria:

- Breastfeeding, pregnant, or expecting to conceive or father children within the
projected duration of the study, starting with the screening through 12 months for
participants who receive cyclophosphamide, or 6 months for participants who do not
receive cyclophosphamide, after the last dose of study treatment

- Prior treatment with chemotherapy, endocrine therapy (ET), targeted therapy, and/or
radiation therapy for the currently diagnosed breast cancer prior to enrollment

- Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or
any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint
pathways

- Significant cardiovascular disease such as left ventricular ejection fraction (LVEF) <
50% at baseline as assessed by echocardiography (ECHO) or multigated acquisition
(MUGA) scan performed at screening, or Class III or IV myocardial disease as described
by the New York Heart Association

- History of ipsilateral invasive BC, regardless of treatment, ipsilateral ductal
carcinoma in situ treated with radiation, or contralateral invasive BC, at any time

- Definitive clinical or radiologic evidence of metastatic disease

- Multicentric BC (the presence of > 1 tumor in different quadrants of the breast)

- Bilateral invasive BC

Other protocol-defined inclusion/exclusion criteria apply