Study of Niacin on Endothelial Function in HIV-infected Subjects With Low High Density Lipoprotein Cholesterol Levels
Status:
Completed
Trial end date:
2010-04-01
Target enrollment:
Participant gender:
Summary
This study is a pilot study examining the effect of extended-release niacin (Niaspan ®) on
flow-mediated vasodilation (FMD) of the brachial artery, among human immunodeficiency virus
(HIV)-1 infected individuals with low high density lipoprotein (HDL). Brachial artery
diameter will be measured by high-resolution ultrasound at entry and week 12 of study. The
primary comparisons will be change in FMD from baseline to 12 weeks within each of the two
arms. The second specific aim will be to investigate the proportion of the effect of
extended-release niacin on other known cardiovascular markers.