Study of Naltrexone-Induced Blockade of Antidepressant Effects
Status:
Completed
Trial end date:
2018-07-15
Target enrollment:
Participant gender:
Summary
The goal of this study is to determine whether antidepressant placebo effects and contextual
cues broadly, can be blocked by one single dose of the µ-opioid antagonist naltrexone. To
test this hypothesis, un-medicated, patients with MDD completed a randomized, double-blind,
placebo-controlled, cross-over study of 50mg of the µ-opioid antagonist naltrexone or
matching placebo, immediately before a Pharmaco-fMRI scanning session.