Overview

Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
OBJECTIVES: I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Center for Research Resources (NCRR)
Collaborator:
Children's Hospital Medical Center, Cincinnati
Treatments:
Magnesium Sulfate
Criteria
PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

- Diagnosis of liver disease with chronic cholestasis Nonsyndromic intrahepatic
cholestasis Alagille's syndrome Extrahepatic biliary atresia

- Direct bilirubin greater than 2 mg/dL OR Bile acids greater than 20 micromoles/L

- No hepatic decompensation defined as one or more of the following: Ascites Peripheral
edema PT at least 4 seconds longer than control Albumin less than 3 g/dL

--Patient Characteristics--

- Renal: No significant renal disease

- Cardiovascular: No significant cardiovascular disease

- Pulmonary: No significant pulmonary disease