Study of Long-Term Antibiotic Treatment in Reactive Arthritis
Status:
Completed
Trial end date:
1998-06-01
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blind, placebo-controlled trial of the effect of 3-month
treatment with the combination of 200 mg ofloxacin twice daily and 150 mg roxithromycin twice
daily on clinical course of recent-onset reactive arthritis. Patients are followed-up at
regular intervals until 6 months. The main outcome measure is recovery from arthritis, and
secondary outcome measures include swollen and tender joint counts, Ritchie index, joint
pain, serum C-reactive protein level and blood erythrocyte sedimentation rate. The study will
also address the safety and tolerability of long-term antibiotic treatment. 56 patients are
enrolled and the enrollment of patients has been completed.