Study of Lactulose in Children With Chronic Liver Disease
Status:
Terminated
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
Pediatric patients with chronic liver disease may have Minimal Hepatic
Encephalopathy(MHE)which can cause changes in behavior,intelligence and neurological
function.By utilizing cognitive and developmental testing we will determine if patients have
MHE. If so, we will trial 3 months of blinded placebo or Lactulose treatment followed by a
washout period with no treatment. At this time patients are re-tested and then begin another
three month period switching to the opposite treatment of first 3 months.Final
cognitive/developmental testing will determine if Lactulose treatment has any effect on MHE.