Study of Intravenous Amino Acid Infusion to Prevent Contrast Dye Mediated Renal Damage
Status:
Withdrawn
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
Exposure to radiographic contrast dye during coronary angiography is well known to cause
either transient decreases in renal function or acute renal failure. Although the overall
incidence is low, acute renal failure occurs most frequently in patients with both diabetes
and chronic renal failure where the average reported incidence is upwards of 20%. The
etiology of contrast-induced nephropathy is related to acute decline in renal blood flow
following dye exposure resulting in ischemic injury at the level of the medulla. The
development of acute renal failure following radiocontrast dye administration is significant
because it contributes to morbidity and mortality in patients at risk.
The administration of amino acids, either through intravenous infusion or a protein meal,
results in a substantial increase in renal plasma flow (RPF) and glomerular filtration rate
(GFR). In both healthy subjects and in those with chronic renal failure, an amino acid
infusion produces a 20% rise in GFR and effective RPF.
We hypothesize that the 20% rise in effective RPF and GFR following an amino acid infusion
will counteract the radiocontrast dye-induced vasoconstriction and reduce the renal toxicity
of contrast medium in a group of high-risk patients.