Study of Glucagon, Ghrelin and Growth Hormone as Counterregulatory Hormones
Status:
Unknown status
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
Glucagon has been used for decades as a test of growth hormone (GH) reserve. The pathway by
which GH is stimulated by glucagon is not established. Acyl ghrelin has been shown to
increase GH levels and to be stimulated by an increase in adrenergic activity. The proposed
study will test the concept that with the fall in blood glucose it is likely that there is a
sympathetic discharge which contributes to the increase in acyl ghrelin and indirectly leads
to the increase in GH and cortisol.