Overview

Study of Gabapentin Extended Release (G-ER)in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women.

Status:
Completed
Trial end date:
2009-10-01
Target enrollment:
0
Participant gender:
Female
Summary
Depomed's Gabapentin Extended Release is an investigational, extended release formulation of gabapentin that is being studied for the treatment of hot flashes in postmenopausal women
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Depomed
Treatments:
Gabapentin
gamma-Aminobutyric Acid
Criteria
Inclusion Criteria:

1. Postmenopausal women aged 18 to 70 years experiencing ≥7 moderate to severe hot
flashes per day (or ≥50 per week) accompanied by sweating during previous 30 days or
longer.

2. Had amenorrhea for ≥12 months, amenorrhea for 6 to 12 months with serum
follicle-stimulating hormone (FSH) levels >40 mIU/mL, or was ≥6 weeks postsurgical
bilateral oophorectomy with or without hysterectomy.

3. Willing to discontinue the following: vaginal hormonal products; transdermal or oral
estrogen or estrogen/progestin combination; intrauterine progestin; progestin
implants; injectable estrogen; topical progesterone cream.

4. Had to have daily average of ≥7 moderate to severe hot flashes and had to complete ≥4
days of diary entries during baseline week to be randomized.

5. If treated with antidepressants, could not have had any changes in drug doses during
past month.

Other Inclusions apply.

Exclusion Criteria:

1. Patient treated with a gonadotrophin releasing hormone agonist, anti-estrogens, or
aromatase inhibitors within 2 months prior to study entry.

2. Patient treated with estrogen pellets or progestin injectable drugs within 6 months
prior to study entry.

3. Patient experience only nighttime hot flashes or worked night shifts on a regular
basis.

4. Patient was concurrently treated with gabapentin for other indications. If patient was
using gabapentin for treatment of hot flashes, she could be screened after a 7-day
washout period provided hot flashes returned.

5. Patient had previously experienced dose-limiting adverse effects that prevented
titration of gabapentin to an effective dose.

6. Patient had a hypersensitivity to gabapentin.

7. Patient was in an immunocompromised state.

8. Patient had a malignancy other than basal cell carcinoma within 2 years prior to study
entry.

9. Patient had gastric reduction surgery, severe chronic diarrhea, chronic constipation,
uncontrolled irritable bowel syndrome, uncontrolled inflammatory bowel disease, or
unexplained weight loss.

10. Patient had clinically significant abnormal chemistry or hematology results, or
calculated glomerular filtration rate <60 mL/min.

11. Patient had history of substance abuse within year prior to study entry.

12. Patient was concurrently taking morphine.

13. Patient had history of chronic hepatitis B or C, hepatitis within 3 months prior to
study entry, or history of human immunodeficiency virus.

Other Exclusions apply.