Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis
Status:
Completed
Trial end date:
2000-03-01
Target enrollment:
Participant gender:
Summary
This is a randonmized, masked, placebo-controlled parallel group, clinical trial to evaluate
the effects of three different doses of N-acetyl L-cysteine (NAC) and placebo on patient
safety and on physical and transport properties of expectorated sputum. Patient sumptoms,
quality of life and exacerbation will also be followed as well as pulmonary function testing
and functional exercise capacity. We hypothesized that a prolongeed course of oral NAC
favorably affects the morbidity of chronic bronchitis, particularly the incidence of acute
exacerbations.