Study of Enzyme Supplements to Treat Celiac Disease

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine whether a cocktail of two common food-grade enzyme supplements leads to decrease of serum activity markers in celiac disease patients insufficiently treated by previous gluten exclusion.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Heim Pal Children's Hospital
• Collaborator: Stanford University

Criteria

Inclusion Criteria:

• Celiac disease diagnosed by small intestinal biopsy

• More than 12 months elapsed since initial diagnosis and start of the dietary treatment

• Evidence for ongoing active disease as verified by seropositivity or dermatitis herpetiformis rash

• Subject agrees to follow a gluten-free diet

Exclusion Criteria:

• Other gastrointestinal or hepatic disease besides celiac disease

• Selective IgA deficiency

• Use of dapsone or diaphenylsulfone

• Pregnancy and breast-feeding