Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity

• Status: Unknown status
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Obesity is often accompanied by insulin resistance and/or hyperinsulinemia. Acanthosis nigricans (AN) is a skin condition commonly present on the neck of obese children. Metformin is a useful drug for conditions characterized by insulin resistance.The aim of this study is to compare the efficacy of metformin versus placebo on AN lesions of the neck as well as their effects on metabolic and anthropometric variables in a sample of obese children. This is a 12-week randomized, double-blind randomized trial involving obese children with AN to receive either metformin or placebo.

Evaluations will be performed every three weeks. Clinical, histological and colorimetric assessments of AN lesions will be compared initially and at the conclusion of the study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Juan Pablo Castanedo-Cazares
• Collaborator: Hospital Central "Dr. Ignacio Morones Prieto"
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Signed informed consent from children and parents.

• Children younger than 18 years.

• Clinical diagnosis of acanthosis nigricans.

• Obesity.

Exclusion Criteria:

• Diabetes mellitus.

• Neurological diseases.

• Congenital diseases.

• Oral treatment for obesity in the last two months.

• Topical treatment for the last two months.