Study of Dexmedetomidine in Spine Surgery

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups. The investigators plan to document the intraoperative opioid requirements, time to first dose of opioids postoperatively and total opioid consumption in the first 24, 48 and 72 hours. The incidence of intra and postoperative complications will be assessed.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Virginia
• Treatments: Dexmedetomidine; Methadone

Criteria

Inclusion Criteria:

• Age 18-80 years of age

• Elective multi-level thoracic and/or lumbar spine surgery requiring SSEP, EMG or MEP monitoring

Exclusion Criteria:

• Emergency spine surgery

• Age < 18 years

• Pregnant patients

• Advanced heart block: Mobitz type II block or atrio-ventricular dissociation in a previous EKG.

• Any individual with stage 4 or greater chronic kidney disease (eGFR< 30 ml/min) and/or requiring dialysis or liver failure defined as a history of cirrhosis or fulminant hepatic failure

• Any individuals on preoperative methadone therapy

• Preoperative dexmedetomidine use

• Preoperative systolic hypertension defined by a systolic blood pressure greater than 150 mmHg in the surgical admission suite

• Enrolled in another study within 30 days