Overview

Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp"

Status:
Unknown status

Trial end date:
2013-03-01

Target enrollment:

Participant gender:

Summary

The objective of this study is to demonstrate the different effects of two DPP-4 inhibitors(Sitagliptin, Saxagliptin)and the insulin secretagogue: glimepiride on first and second phase insulin secretion by using a Biphase-Hyperglycemic Clamp and to explore the different effects of the study drugs on the GLP-1 response, and the glucagon concentration which indicates alpha cell function in healthy subjects.

Phase:

Phase 4

Details

Lead Sponsor:

Shanghai Jiao Tong University School of Medicine

Treatments:

Dipeptidyl-Peptidase IV Inhibitors
Glimepiride
Saxagliptin
Sitagliptin Phosphate