Overview

Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO)

Status:
Recruiting
Trial end date:
2026-05-01
Target enrollment:
Participant gender:
Summary
This research study will add an anti-cancer drug (called inotuzumab ozogamicin also known as "InO") to treatment for participants with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Doctors leading this study hope to learn if adding InO to standard induction treatment for Ph+ ALL will lead to quicker, complete molecular remission (where the disease is not detectable even with very sensitive testing techniques). The purpose of this research is to gather information regarding the effectiveness of InO in newly-diagnosed Ph+ ALL patients that have not yet received treatment.
Phase:
Phase 2
Details
Lead Sponsor:
University of Chicago
Treatments:
BB 1101
Dasatinib
Dexamethasone
Dexamethasone acetate
Inotuzumab Ozogamicin
Methotrexate
Ponatinib
Vincristine