Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15
Status:
Recruiting
Trial end date:
2028-07-31
Target enrollment:
Participant gender:
Summary
The current protocol is to determine the biodistribution, metabolism, excretion and brain
uptake of 11C HY-2-15. The goal of this radiotracer is to quantify alpha-synuclein that is
abnormally deposited in the brain of people with Multiple System Atrophy (MSA). The
investigators will compare uptake in people with MSA with people with Parkinson disease (PD)
and progressive supranuclear palsy (PSP) as well as healthy volunteers. This multicenter
project funded by an NIH U19 grant, is centered at U Pennsylvania (Penn, Grant PI: Robert
Mach) in collaboration with U Pittsburgh (Pitt) (not a clinical site), Yale U, U of
California at San Francisco (UCSF) and Washington University in St. Louis (WU). The
University of Pennsylvania will act as the sIRB for this multi-center human subjects project
and participants will be recruited from all sites.