Study of Bile Acids in Patients With Peroxisomal Disorders
Status:
Terminated
Trial end date:
1999-04-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Determine the effectiveness of oral bile acid therapy with cholic acid,
chenodeoxycholic acid, and ursodeoxycholic acid in patients with peroxisomal disorders
involving impaired primary bile acid synthesis.
II. Determine whether suppression of synthesis of atypical bile acids and enrichment of bile
acid pool with this regimen is effective in treating this patient population and improving
quality of life.