Study of Beet Juice for Patients With Sickle Cell Anemia
Status:
Withdrawn
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesize that increasing plasma nitrite using dietary nitrate will
improve platelet function and red cell deformability and decrease MCHC in patients with
sickle cell disease. The investigators will test this hypothesis through administration of
daily intake of beetroot juice (Unbeetable - Performance Drink) to patients with sickle cell
disease for 28 days. The investigators will evaluate the safety of daily beet root juice
intake in patients with sickle cell disease. In addition, the investigators will measure
MCHC, red cell deformability, and platelet function (activation and aggregation) in response
to daily intake of beet root juice in this patient population.
Phase:
Phase 2
Details
Lead Sponsor:
Daniel Kim-Shapiro Wake Forest University Health Sciences
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) Wake Forest University