Study of Artemether-lumefantrine, Amodiaquine and Primaquine in Healthy Subjects
Status:
Terminated
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
Primary Objective
- To characterize the potential pharmacokinetic interactions of artemether -lumefantrine,
amodiaquine and primaquine in healthy adult subjects.
Secondary Objectives
- To characterize the pharmacokinetic properties of artemether-lumefantrine, amodiaquine
and primaquine when given alone and in combination.
- To evaluate the safety and tolerability of co-administered artemether-lumefantrine,
amodiaquine and primaquine.
- To investigate pharmacogenetic polymorphisms affecting drug levels of
artemether-lumefantrine, amodiaquine and primaquine and their metabolites.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Oxford
Collaborators:
Mahidol Oxford Tropical Medicine Research Unit Mahidol University