Overview
Study of Apatinib and Capecitabine Combination to Maintain Treating Metastatic Colorectal Cancer
Status:
Unknown status
Unknown status
Trial end date:
2018-04-30
2018-04-30
Target enrollment:
0
0
Participant gender:
All
All
Summary
To control apatinib and capecitabine combination to maintain treating metastatic colorectal cancer.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Yanqiao ZhangTreatments:
Apatinib
Benzocaine
Capecitabine
Criteria
Inclusion Criteria:1. Informed consent form should be issued prior to conducting any research process;
2. Men or women aged 18-75 years;
3. Patients with advanced and / or metastatic colorectal cancer confirmed by histology or
cytology;
4. Patients who has not exposed to apatinib previously and had received oxaliplatin
combined with fluorouracil chemotherapy;
5. The estimated survival time is longer than 3 months;
6. ECOG score was 0 or 1;
7. According to the RECIST v1.1 guidance, at least 1 lesion(who had not received
radiotherapy) showed that the longest diameter≥10mm(except for lymph node, the short
axis of the lymph node must be≥15mm) through CT or MRI(intravenous contrast agent was
preferred ) accurate measurement and the lesion should be suitable for repeatable and
accurate measurement; the lesion located in the previously irradiated area can be used
as a measurable lesion if the lesion was proved in progress;
8. With sufficient organ and bone marrow function, defined as follows:
- Hb≥9 g/dL
- Absolute neutrophil count ≥1.0 × 109 /L
- Platelet count≥75 × 109 /L
- Serum bilirubin ≤ 1.5 × ULN, which would not be appropriate for patients with
Gilbert syndrome (Persistent or recurrent hyperbilirubinemia, mainly unconjugated
bilirubin, with no evidence of hemolysis or abnormal liver pathology) which can
consult a doctor
- ALT&AST ≤ 2.5 × ULN; for patients with liver metastases, ALT&AST ≤ 5 × ULN
Calculate the creatinine clearance rate by Cockcroft-Gault formula
- Creatinine clearance rate measured( by actual body weight) or by measuring urine
collection for 24 hours> 40 mL/min(the value of the measurement of the 24 - hour
urine collection will be used to determine eligibility if the two methods are
used)
9. Women of childbearing age must have a pregnancy test (serum or urine) within 7 days
before inclusion, the results should be negative and they are willing to use the
appropriate methods of contraception during the trial and within 6 months of the last
experimental drug administration. Men should agree to use appropriate methods of
contraception during the trial and within 6 months of the last experimental drug
administration;
10. Patients volunteered to participate in the trial and signed informed consent form with
good compliance.
Exclusion Criteria:
1. Patients with hypertension and can not be reduced to the normal range with
antihypertensive drugs(systolic pressure >140 mmHg / diastolic pressure > 90
mmHg),patients with coronary heart disease more than grade II, arrhythmia (including
QTc interval Prolongation men>450 ms, women >470 ms) and cardiac insufficiency;
2. With a variety of factors affecting oral drugs(such as unable to swallow, nausea and
vomiting, chronic diarrhea and intestinal obstruction, etc.);
3. Special note: patients with the risk of gastrointestinal bleeding can not be included,
including the following: active peptic ulcer lesions and fecal occult blood (+ +);
patients with melena and hematemesis in 3 months; for patients with fecal occult blood
(+) and primary gastric tumor without surgery should be carried out gastroscopy,
patients with ulcero carcinoma of stomach and believed to cause the lesion to bleed by
the physician;
4. Abnormal coagulation function(INR>1.5×ULN、 APTT>1.5×ULN) with bleeding tendency;
5. With Symptomatic central nervous system metastasis;
6. Pregnant or lactating women;
7. Other patients unsuitable for inclusion considered by the physician.