Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

• Status: Withdrawn
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aarhus University Hospital
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Linezolid; Teicoplanin; Vancomycin

Criteria

Inclusion Criteria:

• Over 18 years old

• Already having an external CSF drain

• Scheduled for neurosurgery requiring antibiotic prophylaxis (most commonly placement of an internal drain ("shunt")

Exclusion Criteria:

• Infection or colonization requiring other than standard prophylactic antibiotics