Overview

Study in Chinese Healthy Adults to Evaluate the Safety, Tolerability and Pharmacokinetics on ZSP1601, and the Effect of Food on ZSP1601 Pharmacokinetics

Status:
Completed
Trial end date:
2019-03-22
Target enrollment:
0
Participant gender:
All
Summary
This study will evaluate the safety, tolerability and pharmacokinetics (PK) of escalating single- and multiple-oral doses of ZSP1601 on fasted condition, and characterize PK of ZSP1601 on an empty stomach (fasted condition) and following a high fat, high calorie meal (fed condition) in a 2-period, 2-sequence manner. The study will be conducted in 3 parts (Ascending single dose, multiple dose and food effect). Participants will receive either ZSP1601 or placebo .
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Guangdong Zhongsheng Pharmaceutical Co., Ltd.
Criteria
Inclusion Criteria:

- Subjects are required to meet the following criteria in order to be included in the
trial:

1. Signature of a dated Informed Consent Form (ICF) indicating that the subject has
been informed of all the relevant aspects(including adverse events) of the trial
prior to enrollment.

2. Subjects must be willing and able to adhere to the visit schedule and protocol
requirements and be available to complete the study.

3. Subjects(including partners)have no gestation plans and must use reliable methods
of contraception during the study and until 6 months following the last dose of
investigational product.

4. Males and female subjects between 18-50 years (Both inclusive).

5. Body weight is no less than 50kg in males and no less than 45kg in females.Body
mass index (BMI) 18≤BMI≤28 kg/m2; BMI is determined by the following equation:
BMI = weight/height2 (kg/m2).

6. Physical condition:No significant abnormalities in medical history, including
cardiovascular system, liver, kidneys, gastrointestinal system, neural system,
respiratory system (eg.asthma,asthma induced by exercise,chronic obstructive
pulmonary disease), mental, metabolism, etc.

7. Subjects in general good health or No significant abnormalities in the opinion of
the investigator as determined by vital signs and a physical examination.

Exclusion Criteria:

- Eligible subjects must not meet any of the following exclusion criteria:

1. The average daily smoking are more than 5 cigarettes within 3 months prior to
screening.

2. Known hypersensitivity and/or allergy to some drugs and food.

3. Known history of drug or alcohol abuse.(defined as consumption of 14 units of
alcohol per week:1 unit=285ml of beer; or the equivalent of 25ml of spirit, or
100ml of wine )

4. Subjects who donated blood or bleeding profusely(> 400 mL)in the 3 months
preceding study screening.

5. Dysphagia or any medical history in gastrointestinal that interferes with the
absorption of drugs.

6. History or presence of any disease or condition known to increase the risk of
bleeding, eg.acute gastritis, duodenal ulcer, etc.

7. Frequently suffers from postural hypotension.

8. History of frequent nausea or vomit causes by any etiology.

9. Concomitant therapy with any drugs with known hepatic enzyme-inducing or
inhibiting agents that may change the activity of CYP3A4 prior to screening or
during the study.

10. Use of any prescription or over-the-counter (OTC) medications, vitamins and
herbal or dietary supplements within 14 days prior to screening.

11. History of having any special food(including dragon
fruit,mango,grapefruit,etc.),strenuous exercises,or other factors may interfere
with the absorption, distribution, metabolism, or excretion of drug within 14
days prior to screening.

12. Subjects with recent significant change in diet or exercise .

13. Participated in another clinical research study and received any investigational
products within 3 months prior to dosing.

14. Inability to consume the food provided in the study ( a high fat, high calorie
meal includes two eggs for 100g, bacon 20g, a butter toast for 50g, french fries
for 115g, whole milk for 240ml).This requirement only applies to subjects under
fed condition.

15. Presence of clinically significant abnormalities in ECG or QTc>470ms in males,or
QTc>480ms in females.

16. Pregnancy or breastfeeding at screening and during the study.All female subjects
of childbearing potential must have a negative urine pregnancy test at screening
and during the trial.

17. Any clinically significant abnormality upon physical examination or in the
clinical laboratory tests. History or presence of a clinically significant
gastrointestinal, renal, hepatic, neurologic, hematic, endocrine, neoplastic,
pulmonary, immune, psychiatric or cardiovascular and cerebrovascular disorder(s)
(but not limited to above disorders).

18. Presence of human immunodeficiency virus (HIV), viral hepatitis(including
hepatitis C virus (HCV) or hepatitis B virus (HBV) ),treponema pallidum
antibodies at screening.

19. Any acute illness or concomitant medication from screening to first dosing.

20. Have chocolate, any food or beverage that contains caffeine or xanthine within 24
hours prior to dosing.

21. Take any product contains alcohol within 24 hours prior to dosing.

22. Positive for urine drug screening or history of substance abuse for a period of 5
consecutive years before screening.