Study To Evaluate The Effects Of GW856553 On Endothelial Function/Vascular Compliance In Subjects With Dyslipidaemia.
Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
The rationale for this study is to determine whether GW856553 (7.5mg BD for 28 days) has an
effect on endothelial function in dyslipidaemic subjects as assessed by venous occlusion
plethysmography using brachial artery acetylcholine infusion. This will establish consistency
with preclinical findings, as well as confirm a physiologic human response at the current
safe maximal dose. Safety (specifically serum liver function testing) and tolerability will
also be evaluated in this trial.