Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
Human experimental pain models are useful in understanding the mechanisms underlying clinical
pain conditions and can be used to test the analgesic efficacy of drugs used in the
management of pain. Once established these models can be used as mechanism biomarkers in
early development clinical studies to establish proof of mechanism for novel compounds. The
cold pain model is a mechanistic pain biomarker with potential application in proof of
mechanism studies. In this study we aim to set up this cold pain model at a Clinical Research
Unit and demonstrate we can effectively screen subjects for this model and examine the effect
of morphine, diphenhydramine, and gabapentin in the cold pain model.