Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
The primary purpose of this study is to determine the safety and tolerability of moxidectin
in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to
determine whether it is safe enough to expose a number of subjects sufficient for obtaining
statistically significant data on the safety and efficacy of moxidectin relative to
ivermectin.
Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial
indication of the efficacy in terms of long term effect on skin microfilaria levels and an
indication of the effect on the macrofilaria that may underlie the effect on skin
microfilaria levels.
Phase:
Phase 2
Details
Lead Sponsor:
Medicines Development for Global Health World Health Organization