Study 3: Minocycline Decreases Microglia Activation
Status:
Active, not recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
This study is a mechanistic study that will enroll 9 subjects who are participating in
NCT02133885 (which is designed to evaluate minocycline to test the hypothesis that
minocycline treatment would produce antihypertensive effects in drug-resistant neurogenic
hypertensive individuals) to test whether the antihypertensive effect of minocycline is
associated with a decrease in activated microglia in central nervous system autonomic regions
as evidenced by changes in PET and MRI imaging.