Studies of the Ocular Complications of AIDS (SOCA)--Cytomegalovirus Retinitis Retreatment Trial (CRRT)
Status:
Completed
Trial end date:
1995-03-01
Target enrollment:
Participant gender:
Summary
To compare the relative merits of three therapeutic regimens in patients with AIDS and CMV
retinitis who have been previously treated but whose retinitis either is nonresponsive or has
relapsed. These three therapeutic regimens were (1) foscarnet, (2) high-dose ganciclovir, and
(3) combination foscarnet and ganciclovir.
To compare two treatment strategies in patients with relapsed or nonresponsive CMV retinitis:
(1) continuing the same anti-CMV drug or (2) switching to the alternate drug.
Phase:
Phase 3
Details
Lead Sponsor:
Johns Hopkins Bloomberg School of Public Health
Collaborators:
Baylor College of Medicine Icahn School of Medicine at Mount Sinai Johns Hopkins University Memorial Sloan Kettering Cancer Center National Eye Institute (NEI) National Institute of Allergy and Infectious Diseases (NIAID) New York Presbyterian Hospital New York University Northwestern University Tulane University School of Medicine University of California, Los Angeles University of California, San Diego University of California, San Francisco University of Miami University of North Carolina, Chapel Hill University of Wisconsin, Madison