This is a pilot study that aims to evaluate the psychophysiology of premenstrual mood
disorders (PMDs) at baseline and after treatment with sertraline. Participants will include
women with PMDs and healthy male and female controls. Participation involves a baseline visit
to determine eligibility and three study visits that include questionnaires and stress
reactivity assessment via an acoustic startle paradigm, cortisol, and immune markers, as well
as hormone and genetic measures. Female participants with PMDs will receive sertraline during
the premenstrual phase.
Phase:
Phase 4
Details
Lead Sponsor:
Johns Hopkins University University of Pennsylvania