Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The efficacy of esomeprazole will be compared versus cimetidine (a drug that previously demonstrated prevention of bleeding events) during treatment period in proportion of patients for the prevention of upper GI bleeding.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: AstraZeneca
• Treatments: Cimetidine; Esomeprazole

Criteria

Inclusion Criteria:

1. Critically ill patients

2. Requirement for mechanical ventilation

3. At least one major risk factor for stress ulcer related bleeding

Exclusion Criteria:

1. History of gastric or oesophageal surgery

2. Evidence of active GI bleeding

3. Advanced renal disease

4. Treatment with any Proton Pump Inhibitors