Stress CT Perfusion in Patients With Chest Pain

• Status: Completed
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Our hypothesis is that quantitative 3D analysis of cardiac CT images obtained during vasodilator stress can accurately identify patients presenting at the emergency department with acute chest pain due to underlying hemodynamically significant coronary stenosis, aid in the identification of individuals most likely to benefit from revascularization, and thus improve the ability to predict patient outcomes.

Our goals are:

1. to test the above hypothesis by comparing stress MDCT perfusion data with invasive fractional flow reserve (FFR) data in patients with significant stenosis who undergo ICA;

2. to determine the added value of MDCT perfusion as an adjunct to CTCA for predicting patient outcomes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago
• Collaborator: Astellas Pharma Inc
• Treatments: Regadenoson

Criteria

Inclusion Criteria:

• patients with chest pain referred for CT coronary angiography

Exclusion Criteria:

• allergy to iodine,

• renal dysfunction (creatinine >1.6 mg/dL)

• chronic obstructive pulmonary disease

• advanced heart block

• or systolic blood pressure <90 mmHg