Strengthening Hepatitis B Screening, Linkage to Care and Long-Term Monitoring in Phichit Province, Thailand: A Birth Bohort Approach

• Status: NOT_YET_RECRUITING
• Trial end date: 2028-12-31

Summary

This study in Phichit province, Thailand, aims to find and support adults born before 1992 who are at high risk for hepatitis B infection. Many people in this group were born before the universal hepatitis B vaccine was available and may not know they are infected. The study will invite nearly 240,000 eligible adults for free hepatitis B screening. Those who test positive will be linked to care at one of 12 district hospitals. Doctors will use simplified 2024 World Health Organization (WHO) guidelines to decide who needs treatment. Eligible individuals will receive a safe, effective daily medicine (tenofovir alafenamide). The study will use community health volunteers and phone reminders to help patients stay in care and take their medication regularly. Over three years, the study will track improvements in liver health and virus levels, aiming to prevent liver cirrhosis and cancer.

• Phase: PHASE4

Details

• Lead Sponsor: The Task Force for Global Health
• Collaborators: Division of Gastroenterology, Department of Medicine Siriraj Hospital, Mahidol University; Liver Foundation Thailand; Ministry of Health, Thailand; Phichit Provincial Hospital; Phichit Provincial Public Health Office, Ministry of Public Health, Thailand (Host institution); Thai Association for the Study of the Liver
• Treatments: tenofovir alafenamide