Overview

Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition

Status:
Recruiting

Trial end date:
2024-06-14

Target enrollment:
0

Participant gender:
All

Summary

This study to investigate whether empiric use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard-of-care (ampicillin plus gentamicin) will reduce mortality among HIV-infected/HEU children admitted to Mwanamugimu Nutrition Unit, Mulago Hospital, Kampala, Uganda.

Phase:

Phase 2/Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Makerere University

Treatments:

Ampicillin
Ceftriaxone
Gentamicins

Criteria

Inclusion Criteria:

1. HIV-infected children aged 1 to 59 months admitted at Mwanamugimu Nutrition Unit with
severe acute malnutrition

2. HIV exposed but uninfected children aged 1 to 59 months admitted at Mwanamugimu
Nutrition Unit with severe acute malnutrition

3. For prevalence of HIV-infection sub-study, children presenting with severe acute
malnutrition on admission at Mwanamugimu Nutrition Unit.

4. For PK sub-study, the child should have been on antiretroviral therapy for at least
2weeks and should have been in hospital for at least 2weeks.

Exclusion Criteria:

- For PK sub-study; a child with documented poor adherence to antiretroviral therapy.

- For PK sub-study; a child known to have vomited the drug on the sampling day.