Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit
Status:
Completed
Trial end date:
2020-06-16
Target enrollment:
Participant gender:
Summary
To our knowledge, no study has evaluated the independent effects of motivational interviewing
and rate reduction, individually versus in combination, for motivating smokers who are not
ready to quit (SNRTQ) to increase both quit attempts and tobacco abstinence. Given the
disseminability and the fact that findings can be readily translated into the network of
tobacco quitlines, we propose: (1) To test a tobacco quitline for SNRTQ, following methods
that we have previously implemented and evaluated (HL-123978, CA-127964); (2) To randomize
828 SNRTQs to: (a) Brief Advice + typical smoking cessation resources (control group); (b)
motivational interviewing format recommended by the Clinical Practice Guidelines; (c)
behavioral and pharmacologic rate reduction, and (d) both motivational interviewing and
behavioral and pharmacologic rate reduction. This design allows us to evaluate the
independent and additive effects of motivational interviewing and rate reduction on quit
attempts and smoking cessation.
We plan to evaluate the efficacy of the intervention utilizing point prevalence at the
12-month follow-up. The Society for Research in Nicotine and Tobacco consensus paper
concluded that point prevalence (7 days without a cigarette, "not even a puff") is an
appropriate measure in measuring long term outcome in cessation induction trials. Prolonged
abstinence at the 12-month follow-up and quit attempts at the 2-, 4- and 6-month and the
12-month follow-up are secondary endpoints. Self-efficacy, level of smoking reduction,
tobacco dependence, intentions, motivation, and confidence to quit, and intervention
adherence (# sessions attended, amount of nicotine replacement therapy used) will be tested
as important treatment mediators.
Phase:
N/A
Details
Lead Sponsor:
University of Tennessee University of Virginia
Collaborators:
National Cancer Institute (NCI) University of Tennessee