Strategies for Enhancing Mucosal Immunity to Influenza Vaccine
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the safety and effectiveness of the influenza
vaccine when administered nasally and intra-muscular (a "shot" of medicine given into a
muscle). The investigators will measure the systemic (through out the body) and mucosal
immune responses (how your body recognizes and defends itself against bacteria) to nasally
administered influenza vaccine, and determine if nasal immunization results in immunity (your
body's ability to avoid infections) within multiple mucosal compartments (ocular (eye), oral
and reproductive), in comparison with intramuscular administration and placebo (inactive
substance given in the same form as the active drug).