Storytelling to Increase Family Support for Pre Exposure Prophylaxis Use

• Status: Recruiting
• Trial end date: 2022-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV infection but requires high levels of medication adherence, particularly among women. The purpose of this proposal is to evaluate the clinical impact and mechanisms of a family-based storytelling intervention (vs. couples counseling) to improve PrEP adherence and retention among at-risk pregnant/lactating women and their HIV-infected male partners in rural Mozambique. This potentially high impact intervention provides the opportunity to test a culturally relevant approach to PrEP engagement; if proven feasible and effective, family-based storytelling for PrEP engagement could be adopted to reduce HIV incidence among pregnant/lactating women and eliminate mother-to-child transmission (MTCT).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vanderbilt University Medical Center
• Collaborator: Friends in Global Health

Criteria

Inclusion Criteria:

Pregnant women/male partner

1. Discordant couple, one pregnant woman (HIV-) and her HIV+ male partner

2. Both persons must agree to take PrEP (pregnant woman)/ART (male partner)

3. The woman's due date is >4 weeks from study enrollment

4. Both persons must be 18 years or older

5. Both persons (parents) must be willing to consent to an infant record search

6. Neither member of the couple can be under the influence of alcohol at the time of consent.

Family members of expectant couple

1. Must be a relative living in the participants household or living in the study community

2. Must agree to participate in at least one of the storytelling sessions;

3. Must be 18 years of age or older

4. Must not be under the influence of alcohol

5. Must be willing to participate in the interview.

Exclusion Criteria:

Pregnant woman/Male Partner

1. One member of the couple is unwilling to enroll in treatment

Family members

1. Unable to attend storytelling session

2. Expectant couple expresses unwillingness for the family member to participate