Compared to standard treatment goals achieving lower targets for LDL cholesterol (bad
cholesterol) and blood pressure in people with diabetes will slow the progression of
atherosclerosis as measured by carotid artery thickness, and reduce clinical cardiovascular
events such as heart attacks and strokes. This study is a randomized 3-year trial. The
primary endpoint will be a combination of various measures of the carotid artery, (which is
an easy, non-invasive way to detect cardiovascular disease) and events such as heart attacks
and strokes. The study will also look at secondary endpoints such as how well the heart
pumps, fat,protein and inflammatory markers in the blood,and kidney function. The study
enrolled 549 American Indian men and women with diabetes, > 40 years of age and is being
conducted in four field centers involving Indian Health Service/Tribal primary care
facilities in Phoenix/Sacaton, Arizona; Chinle, Arizona; Rapid City/Pine Ridge, South Dakota;
and Lawton, Oklahoma, with input from American Indian physicians and community members.
Phase:
Phase 4
Details
Lead Sponsor:
Cynthia West National Heart, Lung, and Blood Institute (NHLBI)