Steroids and Post-resuscitation Infectious (Septic) Complications
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
Postresuscitation disease is characterized by post-insult systemic inflammation, adrenal
insufficiency, and circulatory failure. Such severe pathology may be associated with
increased susceptibility to infectious complications and increased risk of death due to
postresuscitation septic shock. The latter may be attenuated by stress-dose steroids. In this
re-analysis of synthesized randomized clinical trial (RCT) data, the investigators will use
individual patient data from two prior RCTs of in-hospital cardiac arrest (NCT00411879 &
NCT00729794), in order to determine the effect of stress-dose steroids on the severity of
postresuscitation infectious complications, and more specifically, on the risk of septic
shock-associated death.