Steroid Induced Osteoporosis in Patients With Systemic Lupus Erythematosus
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
The primary aim of the present study was to investigate the prevalence of low bone mineral
density (BMD) and vertebral fractures, as determined by a standardized assessment, and to
elucidate the role of bone qualities, including micro-architecture, bone remodeling, bone
turnover, mineralization and inflammation on bone density and prevalent vertebral fractures
in a large population of systemic lupus erythematosus (SLE) patients.
The secondary aim of the study is to evaluate the following parameters in women with steroid
induced OP (SIOP) before and after 1 year of treatment using:
1. The changes in BMD using dual energy X-ray absorptiometry (DXA)
2. Bone mineralization and architecture in-vivo using a newly available high-resolution
human micro-computed tomography (ExtremCT), which can provide us with new insights into
how the degree and distribution of mineralization are affected by long-term oral
Ibandronate treatment.
3. Changes in perfusion and marrow edema before and after treatment of Ibandronate using
dynamic Magnetic Resonance Imaging (MRI) in these patients with SIOP.
4. The investigators prospectively evaluate the correlation between the changes in brachial
arterial endothelial function and lumbar spine BMD in female lupus patients over the
period of 1 year.