This is a randomized, comparative-effectiveness study comparing intradiscal autologous stem
cells (from bone marrow aspirate) to intradiscal corticosteroid for the treatment of chronic
discogenic low back pain (LBP). The primary objective of this study is to determine whether
intradiscal autologous stem cells (from bone marrow aspirate) is more effective than
intradiscal steroids for the treatment of chronic discogenic low back pain (LBP).
Participants in this study will be randomized to receive up to intradiscal stem cell
injections at 1 or 2 discs with cells harvested from a bone marrow aspirate drawn from
participants' iliac crest, or an equal volume (2 mL) of intradiscal steroids and local
anesthetic injected into the discs. In order to identify the painful disc(s), discography may
be used at the discretion of the provider. Both treatments are frequently used as part of
clinical care (i.e. there is no placebo group).
Phase:
N/A
Details
Lead Sponsor:
Johns Hopkins University
Collaborators:
The Geneva Foundation United States Department of Defense