Stem Cell Transplant to Treat Patients With Systemic Sclerosis
Status:
Completed
Trial end date:
2004-06-01
Target enrollment:
Participant gender:
Summary
Systemic Sclerosis is a disease that may be caused by the immune system reacting against skin
and certain organs. It is possible, that by changing the immune system we can modify the
progression of this disease.
Stem cells are created in the bone marrow. They mature into different types of blood cells
that are needed including red blood cells, white blood cells, and platelets. In this study,
we will stimulate the bone marrow to make extra stem cells. Next we will collect the stem
cells, select specific cells, and store them. We will then give high dose chemotherapy that
will destroy the patients immune system. We will then give back the selected stem cells we
collected. We believe that these selected stem cells may be able to "re-create" the immune
system without the portion that causes Systemic Sclerosis.
The purpose of this study is to try to discover if stem cell transplantation can help
patients with Systemic Sclerosis. We will also try to learn what the side effects are of this
treatment in patients with Systemic Sclerosis. We hope that this treatment will help to
relieve the symptoms patients are experiencing, although we do not know if it will.
Phase:
Phase 1
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Center for Cell and Gene Therapy, Baylor College of Medicine The Methodist Hospital Research Institute The Methodist Hospital System