This study tests the clinical outcomes of one of two preparative regimens (determined by
available donor source) in patients with non-malignant hemoglobinopathies. The researchers
hypothesize that these regimens will have a positive effect on post transplant engraftment
and the incidence of graft-versus-host-disease.
Regimen A2 has replaced Regimen A in this study. Two patients were treated on Regimen A but
did not have evidence of initial engraftment thus triggering the stopping rule for that arm
of this study.