Steady-state Pharmacokinetics of Ceftazidime/Avibactam in Cystic Fibrosis

• Status: Completed
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to characterize the pharmacokinetics of intravenous ceftazidime/avibactam in patients with Cystic Fibrosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Southern California
• Treatments: Avibactam; Avibactam, ceftazidime drug combination; Ceftazidime

Criteria

Inclusion Criteria:

• Diagnosis of CF based on positive sweat chloride or know CF mutation

• Age > 17 years

• Able to spontaneously expectorate sputum

Exclusion Criteria:

• Any clinically significant laboratory abnormality

• Presence of an ongoing acute pulmonary exacerbation

• Pregnancy

• Serious past allergy to a beta-lactam antibiotic