Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

• Status: Terminated
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of our study is to determine the penetration of continuously infused antibiotics at steady state, mainly Meropenem, Vancomycin, Linezolid, Piperacillin/tazobactam and additionally cefepim and ceftazidim, into epithelial lining fluid.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Tuebingen
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ceftazidime; Linezolid; Meropenem; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam; Vancomycin

Criteria

Inclusion Criteria:

• Patients of both gender >0 18 years of age

• Patients of an ICU with one or more of the following infections

• Bacteremia. sepsis

• pneumonia

• tracheo-bronchitis

• mechanical ventilation

• stay on the ICU >= 3 days

• indication for bronchoscopy

Exclusion Criteria:

• pregnancy

• allergy against the studied drug

• known resistance of the involved pathogen against the study drug

• simultaneous participation in other studies

• former participation in the present study

• probable stay on the ICU < 3 days

• contra-indication against the study-drug

• contra-indication for bronchoscopy