Status Asthmaticus on the PICU; Intravenous Salbutamol
Status:
Completed
Trial end date:
2019-05-21
Target enrollment:
Participant gender:
Summary
Although IV salbutamol is frequently used in children in a wide range, pharmacodynamic data
are scarce. To date, there is an insufficient evidence base to guide initial and subsequent
dosing recommendation for its IV use in children. Especially the need for a loading dose
needs to be addressed. Therefore, pharmacodynamic and kinetic data are needed to guide
initial dosing strategies of IV salbutamol in children. To assess the efficacy of a loading
dose of intravenous salbutamol in children admitted to a PICU for severe acute wheeze or
severe acute asthma. Efficacy is measured by the reduction in asthma score (Qureshi) at 1
hour after administration of the loading dose, compared to placebo.