We propose a Phase II, randomized, placebo-controlled clinical trial to test the hypothesis
that treatment with once-daily statins has a beneficial effect on inflammatory cytokines and
clinical outcomes in adults hospitalized with sepsis. As our animal models suggest
pretreatment with statins are required for their beneficial effects, we propose a study
design intended to identify patients and initiate treatment early in their hospital stay.
This Phase II study is intended to assess the feasibility of conducting a large-scale
investigator-initiated translational research protocol that involves multiple clinical
services within the Department of Medicine.