Statins may decrease serum testosterone levels via decreasing cholesterol. This longitudinal
study detected the effects of rosuvastatin on free testosterone levels and sexual function in
men with type 2 diabetes.
Methods:
Investigator enroll 150 men with type 2 diabetes and hypercholesterolemia. Biochemical
assessments include serum total cholesterol (TC), low-density lipoprotein (LDL), high-density
lipoprotein, triglyceride, prolactin, thyroid-stimulating hormone, luteinizing hormone,
follicle stimulating hormone, total testosterone and serum sex hormone binding globulin
(SHBG). All parameters are measured before statin treatment, after 6 months of statin
treatment and 6 months after discontinuing statin treatment. Scores of the sexual health
inventory for men (SHIM) are also evaluated.