Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
The purpose of the research is to see how simvastatin affects a substance in the body called
beta-amyloid. Beta-amyloid is found in the brain and in the liquid around the brain and
spinal cord. High amounts of beta-amyloid may be associated with a greater risk of getting
Alzheimer's disease. This study will see if simvastatin can lower the amount of beta-amyloid
in the spinal fluid. This study will also see if simvastatin affects memory and thinking,
blood flow in the brain, and blood vessel function. The investigators hope that future
studies show whether simvastatin might prevent memory loss and decrease the chance of
developing Alzheimer's disease.