Staph Household Intervention for Eradication (SHINE)

• Status: Recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose a pragmatic comparative effectiveness trial evaluating several decolonization strategies in patients with Staphylococcus aureus infection, their household contacts, and household environmental surfaces. The central hypothesis of this proposal is that an integrated approach of periodic personal and household environmental hygiene will reduce S. aureus transmission in households and subsequently decrease the incidence of skin and soft tissue infections (SSTI).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Chlorhexidine; Chlorhexidine gluconate; Mupirocin

Criteria

Inclusion Criteria:

• Patients 18 years of age and younger

• Confirmed (i.e., culture-positive) active or recent (within the past 2 months) S. aureus cutaneous infections

• Reside within 75 miles of St. Louis Children's Hospital

• Provide written, informed consent, or consent is provided by a parent or legal guardian

Exclusion Criteria:

• Patients with nosocomial infections (i.e., >48 hours after hospitalization)

• Patients with traditional risk factors for HA-MRSA (e.g., immunodeficiency, indwelling catheter or percutaneous medical device, undergoing dialysis, presenting with a surgical site infection, or residing in a long-term care facility within the past year).

• Patients who are unable to give consent or for whom consent is not obtained

• Patients refusing home environmental cultures by the study team

• Patients without a permanent home (e.g., living in a shelter or group home)